Electrical Stimulation for the purpose of helping persons with paralysis of the arms or legs mainly focuses on the neuromuscular transmission peripherally. E-stim can also be used for central nervous system stimulation to hasten awakening from coma or the vegetative state.

Electrical Stimulation is the use of an electrical current to cause a single muscle or a group of muscles to contract.  The contraction of the affected muscle helps strengthen the muscle and it also assists in healing by promoting blood flow to the area.